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April 26 2013

Glowing Plants

I just invested in BioCurious’ Glowing Plants project on Kickstarter. I don’t watch Kickstarter closely, but this is about as fast as I’ve ever seen a project get funded. It went live on Wednesday; in the afternoon, I was backer #170 (more or less), but could see the number of backers ticking upwards constantly as I watched. It was fully funded for $65,000 Thursday; and now sits at 1340 backers (more by the time you read this), with about $84,000 in funding. And there’s a new “stretch” goal: if they make $400,000, they will work on bigger plants, and attempt to create a glowing rose.

Glowing plants are a curiosity; I don’t take seriously the idea that trees will be an alternative to streetlights any time in the near future. But that’s not the point. What’s exciting is that an important and serious biology project can take place in a biohacking lab, rather than in a university or an industrial facility. It’s exciting that this project could potentially become a business; I’m sure there’s a boutique market for glowing roses and living nightlights, if not for biological street lighting. And it’s exciting that we can make new things out of biological parts.

In a conversation last year, Drew Endy said that he wanted synthetic biology to “stay weird,” and that if in ten years, all we had accomplished was create bacteria that made oil from cellulose, we will have failed. Glowing plants are weird. And beautiful. Take a look at their project, fund it, and be the first on your block to have a self-illuminating garden.

October 16 2011

BioCurious opens its lab in Sunnyvale, CA

When I got to the BioCurious lab yesterday evening, they were just cleaning up some old coffee makers. These, I learned, had been turned into sous vide cookers in that day's class.

New lab at BioCurious
New lab at BioCurious

Sous vide cookers are sort of the gourmet rage at the moment. One normally costs several hundred dollars, but BioCurious offered a class for $117 where seventeen participants learned to build their own cookers and took them home at the end. They actually cooked steak during the class--and I'm told that it come out very good--but of course, sous vide cookers are also useful for biological experiments because they hold temperatures very steady.

The class used Arduinos to provide the temperature control for the coffee pots and other basic hardware, so the lesson was more about electronics than biology. But it's a great illustration of several aspects of what BioCurious is doing: a mission of involving ordinary people off the street in biological experiments, using hands-on learning, and promoting open source hardware and software.

Other classes have taught people to insert dyes into cells (in order to teach basic skills such as pipetting), to run tests on food for genetically modified ingredients, and to run computer analyses on people's personal DNA sequences. The latter class involved interesting philosophical discussions about how much to trust their amateur analyses and how to handle potentially disturbing revelations about their genetic make-up. All the participants in that class got their sequencing done at 23andme first, so they had sequences to work with and could compare their own work with what the professionals turned up.

Experiments at BioCurious are not just about health. Synthetic biologists, for instance, are trying a lot of different ways to create eco-friendly synthetic fuels.


BioCurious is not a substitute for formal training in biochemistry, biology, and genetics. But it is a place for people to get a feel for what biologists do and for real biologists without access to expensive equipment to do research of their dreams.

In a back room (where I was allowed to go after being strenuously warned not to touch anything--BioCurious is an official BSL 1 facility, and they're lucky the city of Sunnyvale allowed them to open), one of the staff showed a traditional polymerase chain reaction (PCR) machine, which costs several thousand dollars and is critical for sequencing DNA.

Traditional commercial PCR
Traditional commercial PCR

A couple BioCurious founders analyzed the functions of a PCR and, out of plywood and off-the-shelf parts, built an OpenPCR with open hardware specs. At $599, OpenPCR opens up genetic research to a far greater audience.

BioCurious staffer with OpenPCR
BioCurious staffer with OpenPCR

How low-budget is BioCurious? After meeting for a year in somebody's garage, they finally opened this space three weeks ago with funds raised through Kickstarter. All the staff and instructors are volunteers. They keep such a tight rein on spending that a staffer told me they could keep the place open by teaching one class per week. Of the $117 students spent today for their five-hour class, $80 went to hardware.

BioCurious isn't unique (a similar space has been set up in New York City, and some movements such as synthetic biology promote open information), but it's got a rare knack for making people comfortable with processes and ideas that normally put them off. When executive director Eri Gentry introduces the idea to many people, they react with alarm and put up their hands, as if they're afraid of being overwhelmed by technobabble. (I interviewed Gentry (MP3) before a talk she gave at this year's O'Reilly Open Source Convention.)

Founder and executive director Eri Gentry
Founder and executive director Eri Gentry

BioCurious attacks that fear and miscomprehension. Like Hacker Dojo, another Silicon Valley stalwart whose happy hour I attended Friday night, they wants an open space for open-minded people. Hacker Dojo and BioCurious will banish forever the stereotype of the scientist or engineer as a socially maladroit loner. The attendees are stringently welcoming and interested in talking about what they do in says that make it understandable.

I thought of my two children, both of whom pursued musical careers. I wondered how they would have felt about music if kids weren't exposed to music until junior high school, whereupon they were sat down and forced to learn the circle of fifths and first species counterpoint. That's sort of how we present biology to the public--and then, even those who do show an interest are denied access to affordable equipment. BioCurious is on the cusp of a new scientific revolution.

Eri Gentry with Andy Oram in lab
Eri Gentry with Andy Oram in lab

July 21 2011

OSCON Preview: Interview with Eri Gentry on a biologist's coffeehouse

BioCurious is a Silicon Valley gathering place for biologists and other people such as artists who are fascinated by biology. It serves for learning, sharing, and an incubator for products and ideas. In this interview, community manager Eri Gentry talks about who supports BioCurious, what goes on there, and adventures in synthetic biology and art.

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